Motsoako oa resveratrol le piperine ke mokhoa oa khale
Motsoako oa resveratrol le piperine ke mokhoa oa khale
Motsoako oa resveratrol 'me piperine hajoale e tsejoa e le mokhoa oa khale oa ho ntlafatsa ka ho hlaka ho fumaneha ha resveratrol ka molomo. Mokhoa oa mantlha o kenyelletsa piperine e thibelang li-enzyme tsa metabolism, e liehisa metabolism, le ho khothaletsa ho monngoa ha mala, ka hona e fokotsa haholo tahlehelo e potlakileng ea resveratrol 'meleng.
Ke hobane'ng ha resveratrol e hloka ho eketsa katleho?
Leha ho le jwalo resveratrol (haholo-holo trans resveratrol) e na le monyetla oa ho ba le antioxidant, anti-inflammatory, tšireletso ea pelo le methapo ea mali, anti-botsofali, jj., bioavailability ea eona ka molomo e tlase haholo:
-Ho qhibiliha ha metsi hantle: Ho qhibiliha ha mafura ka matla, ho monya butle ha mala.
-Metabolism ea pele e matla haholo: kamora ho nooa, e fetoloa ka potlako ke glucuronidation le sulfation ka maleng le sebeteng, 'me moriana oa prototype o kena maling ka seoelo haholo.
-Nako e khutšoanyane ea bophelo: Ha e nooa e le 'ngoe, mahloriso a lithethefatsi maling a fihla sehlohlolong kapele 'me a fokotseha ka potlako.
Mokhoa oa tšebelisano-'moho oa piperine (mesebetsi e 3 ea mantlha)
Piperine (alkaloid e sebetsang pepereng e ntšo/pepere e telele) ke sesebelisoa se matla sa ho ntlafatsa ho fumaneha ha lintho tse phelang:
1. Thibela glucuronidation (ea bohlokoa ka ho fetisisa)
Thibela UDP glucuronosyltransferase (UGT) sebeteng le maleng, thibela tsela e ka sehloohong ea metabolism ea resveratrol, fokotsa tlhahiso ea li-metabolite tse sa sebetseng, le ho lelefatsa ho bolokoa ha moriana oa prototype.
2. Thibela ho tsoa ha P-glycoprotein (P-gp)
Thibela pompo ea efflux ea lithethefatsi ea epithelium ea mala, fokotsa ho pompa ha resveratrol ka har'a lumen ea ileal, 'me u ntlafatse ho monngoa ha letlooa.
3. Khothaletsa ho monngoa ha mala le ho liehisa peristalsis ea mala
Fetola sebopeho sa microskeletal mucosa, eketsa phallo ea mali sebakeng seo, eketsa nako ea ho lula, 'me u ntlafatse sekhahla sa ho monngoa ha mali.
Bopaki bo tsoang lipatlisisong tsa liphoofolo le batho
1. Liteko tsa liphoofolo (tse sebetsang hantle haholo)
-Mouse: Resveratrol (100 mg/kg)+Piperine (10 mg/kg) - Keketseho ea tlhoro ea mali (Cmax) e eketsehile ka makhetlo a fetang 15
-Sebaka se ka tlase ho nako ya meriana (AUC, ho pepesehela ka botlalo) se eketsehile ka 229%
-Metabolite e ka sehloohong (resveratrol 3-O-glucuronic acid) AUC ↓ 81%
2. Lithuto tsa batho (ka tekanyo le liphapang tsa motho ka mong)
-Thuto e sa fellang: * * 20 mg ea piperine + resveratrol e nang le tekanyo e phahameng (≥ 1 g) * * e ka eketsa haholo mahloriso le ho pepesehela lithethefatsi maling.
-Liteko tse ling tsa kliniki (tse kang 2.5 g resveratrol+5/25 mg piperine) ha lia ka tsa fihlela bohlokoa ba lipalo-palo, ho bontša hore likarolelano tsa tekanyo, bong, le liphapang tsa metabolism ea motho ka mong li ama katleho.
-Tumellano: Tekanyo e tlase ea piperine (5-20 mg) e kopantsoeng le resveratrol (100-500 mg) e ntse e na le phello e hlakileng ea tšebelisano 'meleng oa motho.
Litlhahiso tse sebetsang tsa karolelano le meriana
1. Likarolelano tse tloaelehileng (tse sebelisoang haholo 'marakeng le lipatlisisong)
-Resveratrol: Piperine=hoo e ka bang 50:1 ho isa ho 20:1
-Mohlala: - Resveratrol 100-200 mg+Piperine 5-10 mg
-Resveratrol 500 mg+Piperine 10-20 mg
2. Lintlha tsa bohlokoa tsa ho nka
-E je le lijo/ka mafura a phetseng hantle (joalo ka linate, oli ea mohloaare) ho ntlafatsa ho monya ha tsona.
Qoba ho nooa hammoho le li-inducer tse matla tsa UGT tse kang rifampicin le phenytoin ho fokotsa katleho.
-Temoso e lokela ho sebelisoa ha ho sebelisoa li-anticoagulant (warfarin, aspirin) hammoho: e ka eketsa litlamorao tsa antiplatelet le ho eketsa kotsi ea ho tsoa mali.
Kakaretso
-Liphoofolo: Piperine e ka eketsa ho fumaneha ha resveratrol ka makhetlo a 'maloa.
- 'Mele oa motho: Tekanyo e tlase ea piperine (5-20 mg) e ka ntlafatsa haholo ho monngoa ha mali le ho eketsa ho pepesehela lithethefatsi maling.
-Mokhoa: E thibela glucuronidation, e thibela phallo ea P-gp, 'me e khothalletsa ho monngoa ha mala.
-Tšebeliso: Metswako e tloaelehileng ea motsoako oa resveratrol, mekhoa ea ho loantša botsofali, ea pelo le methapo ea mali le ea ho thibela ho ruruha
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